Glanzmann thrombasthenia gt is an autosomal recessive disease that is caused by lack of expression or qualitative defects in one of the two gp forming the integrin. The defective gene in glanzmann thrombasthenia is on a type of chromosome that does not decide the sex of the child. Glanzmann thrombasthenia gt is a globally rare inherited disorder of hemostasis. From march 20, 2002 until its 2011 merger into novartis discussed below, alcon was publicly listed and traded on the new york stock exchange under the symbol acl. Glanzmann s thrombasthenia gt is an autosomal recessive inherited bleeding disorder due to a defect in platelet function. Approximately 500 cases have been reported, but many cases have probably not been reported. Signs and symptoms vary greatly from person to person. Glanzmann thrombasthenia was discovered in berne, switzerland in 1918 by a pediatrician named glanzmann.
Its a congenital hemorrhagic disorder, meaning that its a. Glanzmann thrombasthenia gt is a rare inherited blood clotting disorder that is present at birth. Gt is characterized by spontaneous mucocutaneous bleeding and an exaggerated response to trauma due to platelets that fail to. The children affected by the disease all came from a tiny village, called le valais, situated high in the swiss alps. Glanzmann thrombasthenia nord national organization for. Prevalence of the mutations responsible for glanzmann. The international prospective glanzmann thrombasthenia registry.
Glanzmann thrombasthenia is a genetic platelet disorder in which the platelet have qualitative or quantitative deficiencies of the fibrinogen receptor. Background glanzmann thrombasthenia gt is a rare inherited genetic platelet disorder characterized by a qualitative, or quantitative mutation in gpiibiiia receptor. Case a 19yearold arab descent female presented to emergency department with severe menorrhagia. Although it is considered a rare disorder with a global incidence of 11,000,000 population, the case is different at the gulf cooperation council countries, where prevalence rate as high as 140,000 in madinah, saudi. The symptoms of this disease are usually apparent at birth neonates or during infancy. Glanzmanns thrombasthenia an overview sciencedirect. Glanzmann s thrombasthenia gt is a rare inherited platelet disorder, which is characterized by a complete lack of platelet aggregation due to a deficiency or abnormality of the membrane. It has now been established that different genetic mutations of either gpiib or iiia genes results in such a heterogeneity of thrombasthenia phenotype. The genes of both of these proteins are on chromosome 17, and 50% activity of each.
Patients with glanzmann thrombasthenia lacking platelet glycoprotein iib 3 gpiibiiia and v 3 receptors are. Glanzmanns disease, also called glanzmanns thrombasthenia, is a rare condition in which your blood doesnt clot properly. Maintain healthy blood iron levels through appropriate diet. In clinical practice, most of the platelet disorders are due to acquired problems including drugs and metabolic diseases. By using these medicines we create a temporary gtlike situation. Since dr eduard glanzmann s description of thrombasthenia a century ago, several inherited platelet disorders ipds have been identified. If both parents are carriers, the person has a 25% chance of having a child with glanzmann s and a 50% chance that the child will be a carrier. The reported case concerns an 11yearold child admitted to the clinical hematology department of the university hospital mohamed 6 for epistaxis and gingivorrhagia. Glanzmann thrombasthenia is an inherited bleeding disorder characterized by the failure of platelets to aggregate in response to almost all stimuli. Molecular yield of targeted sequencing for glanzmann. Maintain good dental hygiene to avoid gum disease that could lead to bleeding. None of the patients, who have been followed for more than 25 years, has manifested or given a. Glanzmann thrombasthenia gt is a hereditary blood clotting disorder, which is typified by abnormal bleeding. Platelet dysfunction glanzmanns thrombasthenia in horses.
Around 490 mutations in itga2b and itgb3 genes were reported. This case study considers a young woman affected by this disease, integrating the role her culture plays in her medical management. Both boys and girls can have glanzmann s thrombasthenia. This receptor mediates the binding of adhesive proteins that attach aggregating platelets and ensure thrombus formation at sites. Glanzmann thrombasthenia gt is the most frequently encountered inherited disorder of platelet function. Glanzmann thrombasthenia gt is the principal inherited disease of platelets and the most commonly encountered disorder of an integrin. Case report of glanzmann thrombasthenia medical student. Glanzmann s thrombasthenia can be a severe condition, but with the right care and support it can be properly managed. Glanzmann s thrombasthenia is a rare, inherited intrinsic platelet defect involving the platelet. Platelets fail to aggregate in response to stimuli because they lack or have nonfunctional. The hallmark of this disease is severely reducedabsent platelet aggregation in response to multiple physiological agonists. Spontaneous mucocutaneous bleeding is common and can lead to fatal bleeding episodes. People with glanzmann thrombasthenia tend to bruise easily, have frequent nosebleeds epistaxis, and may bleed from the gums. Glanzmann s thrombasthenia is an abnormality of the platelets.
The patients, during their life, show episodes of mucocutaneous bleeding, epistaxis, and gingival bleeding. Glanzmann s thrombasthenia is an autosomal recessive disease that results in a functional deficiency of gpiibiiia receptors. Glanzmann s thrombasthenia is a paradigm for treating coronary artery disease patients with gpiibiiia antibody and inhibitors. Patients with glanzmann thrombasthenia lacking platelet. Glanzmann thrombasthenia is a bleeding disorder that is characterized by prolonged or spontaneous bleeding starting from birth. The molecular basis is linked to quantitative andor qualitative abnormalities of. It is an extremely rare coagulopathy bleeding disorder due to a blood abnormality, in which the platelets contain defective or low levels of glycoprotein iibiiia gpiibiiia, which is a receptor for fibrinogen. Glanzmann thrombasthenia is a hereditary hemorrhagic problem and is characterized by a qualitative or quantitative deficiency of the platelet glycoprotein gpiibiiia, responsible for the reduction of platelet aggregation. Glanzmann thrombasthenia gt is a rare autosomal recessive bleeding syndrome affecting the megakaryocyte lineage and characterized by lack of platelet aggregation. Glanzmann thrombasthenia genetics home reference nih. Glanzmanns thrombasthenia gt is a genetic platelet surface receptor disorder of gpiibiiia itg. Read more about symptoms, diagnosis, treatment, complications, causes and. Glanzmann thrombasthenia, one of the genes on a particular chromosome has a defect.
This means that glanzmann thrombasthenia can affect females as well as males. Glanzmann s thrombastenia gt is the most frequent inherited condition. Glanzmann thrombasthenia genetic and rare diseases. Gt is a genetic autosomal recessive disease caused by the alteration of the genes itga2b and itgb3, located on the chromosome 17. Management of glanzmanns thrombasthenia guidelines. It is characterized by the impaired function of specialized blood cells, called platelets, that are essential for proper blood clotting. Glanzmann, a swiss pediatrician, initially described thrombasthenia in 1918 when he noted purpuric bleeding in patients with normal platelet counts. They may also develop red or purple spots on the skin caused by bleeding underneath the skin petechiae or swelling caused by bleeding.
In this way, it is unlike other bleeding disorders such as as. Platelet glycoprotein iibiiia receptors and glanzmanns. Factor viia recombinante, menometrorragias, histerectomia vaginal thrombasthenia of glanzmann vaginal hysterectomy treated with recombinant factor viia in the present article, regarding a clinical case of thrombasthenia of glanzmann with severe anaemia by menometrorragies, the authors. Glanzmann s thrombasthenia is a rare autosomal recessive bleeding syndrome characterised by a lack of platelet aggregation. This disease emerges from a genetic mutation that affects platelet aggregation. We report the largest international study on glanzmann thrombasthenia gt, an inherited bleeding disorder where defects of the itga2b and itgb3 genes cause quantitative or qualitative defects of the.
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